Challenge Dose

Views Updated: Dec 15, 2025

Abbreviation

Pronunciation

/ˈʧælənʤ doʊs/

All of the rabbits and guinea-pigs vaccinated could resist intracerebral ( ic ) or intramuscular ( im ) challenge with lethal dose of CVS strain.
At the end of the four-month study, both groups were given milk powder as a " challenge " to see what dose would cause reaction after the treatment.
Doing the virus regression test while determining rabies virus neutralizing-antibody, the results showed that the actual dose of virus used for challenge was not consistent with the theoretical dose.
It could elicit efficient viral neutralizing antibody ( VNA ) and protect the dogs from lethal challenge of rabies street strain SBD by intramuscular inoculation at dose of only 1.6 × 106PFU.
For example, a major challenge of modern medicine is that the body doesn't absorb the entire drug dose given to a patient.

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