Germinal Center

Views Updated: Dec 15, 2025

Abbreviation

Pronunciation

/ˈdʒɜːrmɪnəl ˈsɛntər/

Each follicle contains a germinal center populated by rapidly proliferating B cells and macrophages.
Lymphoid follicles within the lymph node hyperplasia, a marked expansion of germinal center, surrounded by small lymphocytes.
This is a more pronounced reactive change in a lymph node, with a larger follicle and germinal center containing macrophages.
Objective To explore the relationship between sinus histiocytosis ( SH ) and germinal center hyperplasia ( GH ) in axillary lymph nodes and lymph node metastases of breast cancer of T1-2 stage.
Whether E2F1 can be used as a germinal center B cell DLBCL marker was also discussed.

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