noncompetitive antagonist

Views Updated: Dec 15, 2025

Abbreviation

NCA

Pronunciation

/ˌnɑnkəmˈpɛtətɪv ænˈtægənəst/

A noncompetitive antagonist(NCA) prevents the agonist from producing any effect at a given receptor site.
Ketamine is a NMDA receptor noncompetitive antagonist(NCA), which has been administered clinically to treat acute or chronic pain syndrome. A lot of study have been carried about its effect of preemptive analgesia, but we have different results.
Objective To investigate the effects of magnesium sulfate, a noncompetitive antagonist(NCA) of glutamate receptor, in focal cerebral ischemic injury of rats.
BACKGROUND : Ketamine is a kind of frequently used general venous anesthesia drug in clinic, and the medication in vein or epidural cavum has analgesic effect. It is N-methyl-D-aspartic acid ( NMDA ) receptor noncompetitive antagonist(NCA), which can inhibit toxic effect of excitatory amino acids.
It was obviously that Glu have toxicity to neurons at the 12th cultured day. Noncompetitive NMDA receptor antagonist, MK-801, could reduce ratio of neuron death and apoptosis induced by Glu.

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