OMGD Views 5 meanings found OMGD is both an informal exclamation in online chat and a medical abbreviation for obstructive meibomian gland disease, with occasional use by niche organizations. Medical Obstructive meibomian gland disease Miscellaneous Ordre Mondial des Gourmets Dégustateurs Obsessive Male Gender Disorder Oh My God Dude Business Omnigene Diagnostics, Inc.