Reciprocal Chromosomal Translocation

Views Updated: Dec 15, 2025

Key Facts

Abbreviation
RCT
Pronunciation
/rɪˈsɪprəkəl kroʊˈmoʊsəmæl trænsloʊˈkeɪʃən/
Category
Medical
Related Field
British Medicine

Examples in Context

  1. Background and objective : Philadelphia chromosome ( Ph ) is the result of a t ( 9; 22 ) reciprocal chromosomal translocation and is the malignant clonal marker of chronic myeloid leukemia ( CML ).
  2. Its cytogenetic hallmark is a reciprocal t ( 9; 22 ) chromosomal translocation known as the Philadelphia chromosome and this translocation results in the formation of chimeric fusion gene BCR / ABL which is thought to play a central role in the pathogenesis of CML.

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