WLE Views 8 meanings found WLE is best known in medicine as the term for a surgical technique that removes a localized lesion, whereas in tech it can denote a whitelist‑based email verification system and in transportation it names a historic railroad. Medical Wide Local Excision Miscellaneous Wine Lohr Enthusiast Governmental Wing Leading Edge Regional Wheeling and Lake Erie Railroad Computing White List Email, email confirmation system Business Wing Lam Enterprises White Light Enterprises, Inc. Sports Weight- Lifting Encyclopedia