XYZ Views 5 meanings found XYZ is an informal internet acronym used humorously to tell someone to check their zipper, and it also serves as a placeholder for the three spatial axes (X, Y, Z) in technical contexts. Community Xtra Years Of Zest Academic & Science Horizontal, Vertical, Depth Computing Examine Your Zipper Internet Xamine Your Zipper eXcuse me, Your Zipper